Proluton Depot 250 mg/mL Injection 1's is a long-acting hydroxyprogesterone-caproate intramuscular injection used in specialist gynecological or obstetric care for selected progesterone-responsive conditions. Its confirmed composition is Hydroxyprogesterone caproate 250 mg in 1 mL oily solution for intramuscular injection.

A trained healthcare professional gives the 1 mL injection slowly and deeply into a large muscle. The dose interval and treatment duration depend on the selected indication and must be recorded in the specialist treatment plan. Do not inject into a vein.

Injection-site pain, swelling, nausea, headache, breast tenderness, fluid retention or mood change may occur. Seek urgent care for leg swelling, sudden chest pain, breathing difficulty, jaundice, severe headache, visual changes or a severe allergic reaction. Seek medical or pharmaceutical advice if symptoms are severe, persistent or worsening.